Resource Type

Journal Article 119

Year

2024 2

2023 10

2022 4

2021 9

2020 4

2019 12

2018 6

2017 5

2016 8

2015 6

2014 1

2013 5

2012 3

2011 2

2010 7

2009 18

2008 9

2007 4

2003 2

open ︾

Keywords

Alzheimer’s disease 4

DNA 3

prognosis 3

Drug discovery 2

E3 ubiquitin ligase 2

Hepatocellular carcinoma 2

MERS-CoV 2

N-glycosylation 2

Polycyclic aromatic hydrocarbons 2

Protein 2

Spike protein 2

atom transfer radical polymerization 2

food security 2

hepatocellular carcinoma 2

resistance 2

β 1

-catenin 1

Brucella melitensis 1

Manihot esculenta 1

open ︾

Search scope:

排序： Display mode:

Correlativity study between expression of DNA double-strand break repair protein and radiosensitivity

Liang ZHUANG, Shiying YU, Xiaoyuan HUANG, Yang CAO, Huihua XIONG

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 26-29 doi: 10.1007/s11684-009-0008-7

Abstract: Ku80, DNA-PK catalytic subunit (DNA-PKcs) and ataxia telangiectasia mutated (ATM) proteins are majorclone formation assay, and western blot was applied to detect the expressions of Ku80, DNA-PKcs and ATM proteinThe correlativity of protein expression with SF2 value was analyzed by Pearson linear correlation analysisWe found that the expression of same protein in different cell lines and the expression of three proteinsThese findings suggest that the expression level of DNA-PKcs protein can be an indicator for predicting

Keywords： Ku80     DNA-PK(cs)-binding protein     human     ataxia telangiectasia mutated protein     tumor cell lines     radiosensitivity    

HTML PDF Collect

Functional role of ATM in the cellular response to DNA damage

Ming LIU, Wenxiang HU

Frontiers of Chemical Science and Engineering 2011, Volume 5, Issue 2,   Pages 179-187 doi: 10.1007/s11705-009-0268-4

Abstract: Ataxia-telangiectasia mutated (ATM) plays a key role in regulating the cellular response to ionizingThe tumor-suppressor gene ATM, mutations in which cause the human genetic disease ataxia telangiectasia, encodes a key protein kinase that controls the cellular response to double-stranded breaks.

Keywords： ataxia-telangiectasia mutated (ATM)     cell cycle checkpoint     DNA damage     signalling transduction    

HTML PDF Collect

ANTIVIRAL EFFECTS OF BACTERIOCIN AGAINST ANIMAL-TO-HUMAN TRANSMITTABLE MUTATED SARS-COV-2: A SYSTEMATIC

Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 4,   Pages 603-622 doi: 10.15302/J-FASE -2021397

Abstract:

The COVID-19 infections caused by SARS-CoV-2 have resulted in millions of people being infected and thousands of deaths globally since November 2019. To date, no unique therapeutic agent has been developed to slow the progression of this pandemic. Despite possessing antiviral traits the potential of bacteriocins to combat SARS-CoV-2 infection has not been fully investigated. This review summarizes the mechanisms by which bacteriocins can be manipulated and implemented as effective virus entry blockers with infection suppression potential properties to highly transmissible viruses through comprehensive immune modulations that are potentially effective against COVID-19. These antimicrobial peptides have been suggested as effective antiviral therapeutics and therapeutic supplements to prevent rapid virus transmission. This review also provides a new insight into the cellular and molecular alterations which have made SARS-CoV-2 self-modified with diversified infection patterns. In addition, the possible applications of antimicrobial peptides through both natural and induced mechanisms in infection prevention perspectives on changeable virulence cases are comprehensively analyzed. Specific attention is given to the antiviral mechanisms of the molecules along with their integrative use with synthetic biology and nanosensor technology for rapid detection. Novel bacteriocin based therapeutics with cutting-edge technologies might be potential substitutes for existing time-consuming and expensive approaches to fight this newly emerged global threat.

 

Keywords： antiviral profiling of bacteriocins / antiviral therapeutics / immunomodulation / nanosensor technology / mutated    

HTML PDF Collect

Decitabine induces -mediated immune responses in p53-mutated triple-negative breast cancer: a clinical

Frontiers of Medicine doi: 10.1007/s11684-023-1016-8

Abstract: p53 is mutated in half of cancer cases. However, no p53-targeting drugs have been approved.immune responses featuring the striking upregulation of the innate immune player IRF7 in the p53-mutatedOur integrative studies reveal the potential of repurposing decitabine for the treatment of p53-mutated

Keywords： p53 mutation     triple-negative breast cancer     decitabine     DNMT1     IRF7     innate immune response    

HTML PDF Collect

Systems understanding of plant–pathogen interactions through genome-wide protein–protein interaction

Hong LI,Ziding ZHANG

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 2,   Pages 102-112 doi: 10.15302/J-FASE-2016100

Abstract: great opportunity to explore plant–pathogen interactions from a systems perspective and studies on protein–protein

Keywords： plant–pathogen interactions     systems biology     omics     plant immunity     protein–protein interaction     network    

HTML PDF Collect

Observation of a higher JAK2 V617F homozygous mutated clone in polycythemia vera compared to essential

LIU Hongxing, TONG Chunrong, CAI Peng, GU Jiangying, LIN Yuehui, TENG Wen, WANG He, ZHANG Ying, ZHU Ping

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 309-313 doi: 10.1007/s11684-008-0059-1

Abstract: Single-tube bi-directional allele specific amplification (SB-ASA) and real-time quantitative polymerase chain reaction (RQ-PCR) assays were developed and performed for JAK2V617F detection on 40 polycythemia vera (PV) samples, 31 essential thrombocythemia (ET) samples, 40 acute leukemia samples, and 40 healthy control samples. Differences between detect limitations of the two assays and their influence on the mutation detection rate were analyzed. The results showed that in some samples, the JAK2V617F burden was as low as nearly 1%, and thus more JAK2V617F-positive samples were detected by RQ-PCR than by SB-ASA assay due to the former higher detect limitation. Mutation allele ratios in PV and ET samples and their relevance to biological characteristics were also analyzed. The results showed that the mutation allele ratio was 0.436 ± 0.261 in PV, higher than the 0.216 ± 0.207 in ET; percentage of certainly homozygous mutation carriers in PV was 40.54%, higher than the 10% in ET. However, statistical analysis showed no relevance between mutation allele burden and sex or age. Our result shows that the pathogenesis of PV and ET may be related to the mutation allele burden of JAK2V617F.

Keywords： specific amplification     essential thrombocythemia     Single-tube bi-directional     JAK2V617F-positive     JAK2V617F detection    

HTML PDF Collect

The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases

Yuan CHEN, Qi TIAN

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 70-76 doi: 10.1007/s11684-011-0119-9

Abstract:

Protein kinase C epsilon (PKC ?) is one of major isoforms in novel PKC family.

Keywords： protein kinase C ?     signal transduction     neurogenic disease    

HTML PDF Collect

Wheat gluten protein and its impacts on wheat processing quality

Wujun MA, Zitong YU, Maoyun SHE, Yun ZHAO, Shahidul ISLAM

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 3,   Pages 279-287 doi: 10.15302/J-FASE-2019267

Abstract: Wheat grain protein is divided into gluten and non-gluten fractions and the wheat processing qualityBased on the SDS-extractability, grain protein is divided into SDS-unextractable polymeric protein (UPP) and SDS-extractable polymeric protein.

Keywords： wheat gluten     consensus motifs     disulfide bonds     SDS-unextractable polymeric protein     glutenins     gliadins     processing quality     storage protein    

HTML PDF Collect

Construction of sustainable, colored and multifunctional protein silk fabric using biomass riboflavin

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 8,   Pages 1131-1139 doi: 10.1007/s11705-023-2321-0

Abstract: modification of silk fabric by impregnation with riboflavin sodium phosphate was proposed, such that protein

Keywords： biomass     riboflavin sodium phosphate     silk protein     multifunctional modification     flame retardant    

HTML PDF Collect

Antithrombin deficiency and decreased protein C activity in a young man with venous thromboembolism:

Dong Wang, Min Tian, Guanglin Cui, Dao Wen Wang

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 319-323 doi: 10.1007/s11684-017-0553-4

Abstract:

Antithrombin and protein C are two crucial members in the anticoagulant system and play importantCoagulation tests revealed that the patient presented type I antithrombin deficiency combined with decreased proteinThis study demonstrates that the combination of antithrombin deficiency and decreased protein C activity

Keywords： antithrombin deficiency     protein C activity     mutation     variant     venous thromboembolism     anticoagulants    

HTML PDF Collect

Interspecies transmission and evolution of the emerging coronaviruses: perspectives from bat physiology and protein

Baicheng HUANG, Kegong TIAN

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 2,   Pages 218-226 doi: 10.15302/J-FASE-2020324

Abstract: The relationship of spatial structural characteristics of the spike protein, a protein that is critical

Keywords： bat     coronavirus     evolution     host receptor     spike protein     transmission    

HTML PDF Collect

Elevated C-reactive protein levels predict worsening prognosis in Chinese patients with first-onset stroke

Jiangtao YAN, Rutai HUI, Daowen WANG

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 30-35 doi: 10.1007/s11684-009-0005-x

Abstract: The role of high sensitivity C-reactive protein (hsCRP) in predicting prognosis after stroke in the Asian

Keywords： C-reactive protein     inflammation     stroke    

HTML PDF Collect

Recombinant protein diannexin prevents preeclampsia-like symptoms in a pregnant mouse model via reducing

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 919-931 doi: 10.1007/s11684-021-0918-6

Abstract: This study describes a strategy to prevent PE by reducing MP release using the recombinant protein, diannexin

Keywords： preeclampsia     recombinant protein diannexin     microparticle     NLRP3 inflammasome     phosphatidylserin    

HTML PDF Collect

Investigation of hydrolysis conditions and properties on protein hydrolysates from flatfish skin

Hua ZHANG, Hongji ZHU, Shipeng WANG, Weihua WANG

Frontiers of Chemical Science and Engineering 2013, Volume 7, Issue 3,   Pages 303-311 doi: 10.1007/s11705-013-1341-6

Abstract: based on Box-Behnken design, was used to optimize the enzymatic hydrolysis conditions of flatfish skin protein

Keywords： flatfish skin     protein hydrolysates     metal chelating activity     reducing power    

HTML PDF Collect

Protein phosphatase 2A, a key player in Alzheimer’s disease

Rong LIU, Qing TIAN

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 8-12 doi: 10.1007/s11684-009-0017-6

Abstract: Protein phosphatase 2A (PP2A) is the predominant serine/threonine phosphatase in eukaryotic cells.is suggested to be involved in neurofibrillary tangle (NFT) formation, disturbed amyloid precursor protein

Keywords： protein phosphatase 2A     Alzheimer’s disease     holoenzyme composition     protein phosphatase 2A inhibitors     Leu309    

HTML PDF Collect

Title Author Date Type Operation

Correlativity study between expression of DNA double-strand break repair protein and radiosensitivity

Liang ZHUANG, Shiying YU, Xiaoyuan HUANG, Yang CAO, Huihua XIONG

Journal Article

Functional role of ATM in the cellular response to DNA damage

Ming LIU, Wenxiang HU

Journal Article

ANTIVIRAL EFFECTS OF BACTERIOCIN AGAINST ANIMAL-TO-HUMAN TRANSMITTABLE MUTATED SARS-COV-2: A SYSTEMATIC

Journal Article

Decitabine induces -mediated immune responses in p53-mutated triple-negative breast cancer: a clinical

Journal Article

Systems understanding of plant–pathogen interactions through genome-wide protein–protein interaction

Hong LI,Ziding ZHANG

Journal Article

Observation of a higher JAK2 V617F homozygous mutated clone in polycythemia vera compared to essential

LIU Hongxing, TONG Chunrong, CAI Peng, GU Jiangying, LIN Yuehui, TENG Wen, WANG He, ZHANG Ying, ZHU Ping

Journal Article

The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases

Yuan CHEN, Qi TIAN

Journal Article

Wheat gluten protein and its impacts on wheat processing quality

Wujun MA, Zitong YU, Maoyun SHE, Yun ZHAO, Shahidul ISLAM

Journal Article

Construction of sustainable, colored and multifunctional protein silk fabric using biomass riboflavin

Journal Article

Antithrombin deficiency and decreased protein C activity in a young man with venous thromboembolism:

Dong Wang, Min Tian, Guanglin Cui, Dao Wen Wang

Journal Article

Interspecies transmission and evolution of the emerging coronaviruses: perspectives from bat physiology and protein

Baicheng HUANG, Kegong TIAN

Journal Article

Elevated C-reactive protein levels predict worsening prognosis in Chinese patients with first-onset stroke

Jiangtao YAN, Rutai HUI, Daowen WANG

Journal Article

Recombinant protein diannexin prevents preeclampsia-like symptoms in a pregnant mouse model via reducing

Journal Article

Investigation of hydrolysis conditions and properties on protein hydrolysates from flatfish skin

Hua ZHANG, Hongji ZHU, Shipeng WANG, Weihua WANG

Journal Article

Protein phosphatase 2A, a key player in Alzheimer’s disease

Rong LIU, Qing TIAN

Journal Article